Neuroscience
See neural tissues clearly
The high heterogeneity and autofluorescence of brain and neural tissue present technical challenges when using conventional imaging techniques to decipher different cell types and intricate spatial relationships in the study of neurodegenerative disease or neuro-oncology.
Imaging Mass Cytometry™ (IMC™) produces clear, easy-to-interpret signals from neural tissue, eliminating autofluorescence interference with metal-labeled antibodies.
Download neuroscience bibliography
Application of neuro-oncology IMC panel on human and mouse tumors of mixed or non-glial origin
Mapping the neuro-oncological cellular landscape
Spatial phenotyping with IMC enables comprehensive assessment of the structural and cellular organization of the tumor microenvironment in neural tissues, including activation of immuno-oncological processes.
Neuro-oncology panel kits for Imaging Mass Cytometry
Identify neural cell lineages and immune cell infiltration in spatial context to better understand disease progression.
Try one of our ready-made panels or bundles or explore our comprehensive catalog of immune markers. Our easy panel design process makes integrating new markers simple.
Learn about the power of the high-plex Maxpar OnDemand Mouse Neuro-Oncology IMC Bundle to enable single-cell analysis for fast and accurate brain tumor and immune cell phenotyping.
Study neurodegeneration spatial complexity in context
Pathological proteins have emerged as a common mechanism for the progression of various neurodegenerative diseases. Discover the spatial distribution of these key proteins in neural tissues using pre-designed IMC panels for the study of neurodegenerative diseases in formalin-fixed, paraffin-embedded (FFPE) tissue sections.
Products
Get critical insights into common neurodegenerative proteinopathies or mixed pathologies as seen in synucleinopathy and tauopathy neurodegenerative conditions.
Alzheimer's Disease IMC Panel, 3 Antibodies
The Alzheimer’s Disease IMC Panel is a bundle of three verified Maxpar OnDemand antibodies against Tau, phosphorylated Tau (pTau) and amyloid precursor protein (APP).
Parkinson's Disease IMC Panel, 3 Antibodies
The Parkinson’s Disease IMC Panel is a bundle of three verified Maxpar OnDemand antibodies against αSynuclein (αSyn), phosphorylated αSynuclein (p-αSyn) and tyrosine hydroxylase (TH).
Multiple Sclerosis IMC Panel, 3 Antibodies
The Multiple Sclerosis IMC Panel is a bundle of three verified Maxpar OnDemand antibodies against human- and mouse-reactive myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG) and pan-axonal neurofilament (NF) protein.
Proteinopathies IMC Panel, 5 Antibodies
The Proteinopathies IMC Panel, 5 Antibodies is a bundle of 5 verified Maxpar OnDemand Antibodies against Tau, pTau, αSyn, p-αSyn, and APP. By leveraging these validated antibodies, researchers can visualize cellular landscape of common neurodegenerative proteinopathies such as Alzheimer’s disease, Parkinson’s disease, Parkinson’s disease with dementia, Lewy body dementia, and similar conditions. This panel is optimized for use in FFPE tissue sections. APP, Tau, and αSyn are human and mouse reactive, while p-αSyn and pTau recognize human epitopes [S129] and [S202/T205], respectively, and can be used in mouse models that exogenously express these human proteins.
SynTau Mixed Pathology IMC Panel, 4 Antibodies
The SynTau Mixed Pathology IMC Panel, 4 Antibodies is a bundle of 4 verified Maxpar OnDemand Antibodies designed for unraveling the complexities of mixed pathologies as seen in synucleinopathy and tauopathy neurodegenerative conditions. These antibodies specifically target Tau, pTau, αSyn, and p-αSyn. This panel is optimized for use in FFPE tissue sections and can be used in mouse models that exogenously contain human epitopes for p-αSyn and pTau. Both Tau and αSyn are cross-reactive for human- and mouse-specific targets, while p-αSyn and pTau recognize human epitopes [S129] and [S202/T205], respectively.
Add compatible panels for deeper insights
Capture a more complete view of neurodegeneration by combining any neurodegeneration panel with human immuno-oncology IMC subpanels, the Maxpar Neuro Phenotyping IMC Panel Kit, the Maxpar IMC Cell Segmentation Kit and Cell-ID™ Intercalator.
Webinar: Spatial Dissection Of Tumor Immune Microenvironment
Daniela Quail, PhD
Assistant Professor, Rosalind and Morris Goodman Cancer Institute and Department of Physiology, McGill University
Quail describes the use of Imaging Mass Cytometry to understand immune dynamics in tumors – first in the brain tumor microenvironment to identify new cell populations that might help understand tumor biology and second in non-small-cell lung cancer patients to predict recurrence and survival outcomes.
Unless explicitly and expressly stated otherwise, all products are provided for Research Use Only, not for use in diagnostic procedures. Find more information here.